Zynamite (Mangifera indica)
A 2020 RCT (Lopez et al.) found 300mg Zynamite acutely improved reaction time, attention, and working memory versus placebo. A 2019 sports performance study showed Zynamite + luteolin (Dynamine) improved repeated sprint performance and cognitive function under physical fatigue. Evidence base is small but growing — Nektium (the manufacturer) funds most research.
Mechanism of action
Zynamite is a patented extract of Mangifera indica (mango leaf) standardised to >60% mangiferin. Mangiferin is a potent polyphenol that inhibits catechol-O-methyltransferase (COMT), slowing the breakdown of dopamine and norepinephrine in the prefrontal cortex. This extends the active duration of catecholamines without increasing their production — a unique mechanism distinct from precursor-loading (L-Tyrosine) or synthesis-boosting (caffeine) approaches. Additionally, mangiferin has anti-inflammatory and antioxidant properties.
Clinical evidence summary
A 2020 RCT (Lopez et al.) found 300mg Zynamite acutely improved reaction time, attention, and working memory versus placebo. A 2019 sports performance study showed Zynamite + luteolin (Dynamine) improved repeated sprint performance and cognitive function under physical fatigue. Evidence base is small but growing — Nektium (the manufacturer) funds most research.
Human effect matrix
Based on human clinical trials only. Animal and in-vitro data excluded.
| Effect | Evidence | Magnitude | Studies |
|---|---|---|---|
| Reaction Time | moderate | Moderate | 2 |
| Working Memory | preliminary | Small | 2 |
| Physical-Cognitive Dual Task | preliminary | Moderate | 1 |
Evidence key: Strong = multiple consistent RCTs · Moderate = smaller/fewer RCTs · Preliminary = early trials or small n · Mixed = conflicting results
Documented benefits
- Extended dopamine activity
- Improved reaction time
- Cognitive support under fatigue
- Anti-inflammatory
Side effects & cautions
- Generally well tolerated
- Mild GI discomfort rare
- Limited long-term safety data
- Possible interaction with MAO inhibitors
How to take
Stacking recommendations
Ingredients that pair well with Zynamite (Mangifera indica) and why.
Caffeine increases catecholamine release; Zynamite slows their breakdown via COMT inhibition. Together they produce a stronger, longer-lasting dopamine signal.
Tyrosine provides dopamine precursor; Zynamite slows dopamine metabolism. Supply + preservation for sustained catecholamine levels.
L-Theanine smooths out any overstimulation from Zynamite's catecholamine-preserving effects. Balanced energy without agitation.
Frequently asked questions
Is Zynamite just mango leaf extract?
Zynamite is a specific patented extract of Mangifera indica standardised to >60% mangiferin. Generic mango leaf supplements may contain far less mangiferin and are not equivalent. The clinical trials used Zynamite specifically.
Is the evidence independent or manufacturer-funded?
Most Zynamite studies are funded or co-funded by Nektium, the manufacturer. This is common for patented ingredients but means independent replication is limited. The existing trials are well-designed (double-blind, placebo-controlled) but should be interpreted with this funding context in mind.
Can I take Zynamite with caffeine?
Yes — this is actually one of the studied combinations. Zynamite + caffeine showed synergistic effects on reaction time in the sports performance trial. However, monitor your total stimulant load since Zynamite extends catecholamine activity.
Zynamite (Mangifera indica) in Australia
Products in Australia
None of the stacks we have audited currently ship in Australia.
TGA (AUST L)
State & territory guides
Regulatory note
Therapeutic goods available in Australia are regulated by the Therapeutic Goods Administration (TGA). AUST L–listed products carry pre-approved permitted indications; AUST R–registered products are higher-evidence. Imported products without TGA listing are not assessed by Australian regulators. This page is editorial, not promotional, and does not constitute medical advice. Always read the label and follow directions for use. Consult a qualified healthcare professional before starting any supplement.